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Saturday, October 7, 2017

Linda's Family of Nutz: CH CH CH Changes!!!

Linda's Family of Nutz: CH CH CH Changes!!!: Changes are coming!!! On Aug 3, 2017, Legacy and My Heritage announced that their companies were merging.  Shock rippled across the Gen...

Tuesday, December 13, 2016

The African Diaspora Integrating Culture, Genomics and History





Feature Story: The African Diaspora





Researcher draws human pedigree on window

The African Diaspora: Integrating Culture, Genomics, and History


Identity, Health, and Personal Ancestry Come Together
by Jacquelyn K. Beals
The genetic techniques have to be combined with anthropological knowledge, with historical knowledge and, ultimately, the people who we’re discussing have a say in their identity… Identity is more than just the science, it’s also the culture.  
 Fatimah Jackson, UNC Chapel Hill
The Smithsonian and the National Human Genome Research Institute in September
2013  co-hosted a symposium on the African Diaspora: Integrating Culture,
Genomics, and History (view video), in conjunction with the “Genome Unlocking
 Life’s Code”
 exhibition.  “The Symposium explored how historical and genomic information is
 used to understand identity, health, culture and personal ancestry," stated
Vence Bonham, chair of the planning committee.
With advances in technology, a younger group of genealogists now searches for their
personal history and identity using genomic analyses and Internet search engines.
 Symposium speaker Dr. Alondra Nelson showed a typical group of genealogists
when her research started a decade ago. “It tended to be a pursuit of older folks,
older African-Americans,” said Dr. Nelson. Today she’s “trying to make connections
with younger genealogists, and you find a lot of these on YouTube.” For younger
 African-Americans, genealogy is less about archival research and more about
 cutting-edge DNA ancestry testing and its results. 
Dr. Nelson’s shared the story of a young
Black woman who’d just received her
genetic ancestry test results and called
 her grandmother  to share the
results. “Grandma,” she said
 excitedly, “we’re from Cameroon!”
After a pause her grandma replied: “No,
we’re from South Carolina.”

And therein lies the big question – where is
 anyone from, really? And another
compelling question – what can our origins
 tell us about ourselves? People used to
 answer these questions  by following paper
 trails. Has DNA testing made genealogy
 simpler or more complex?  It depends
who you ask.
Where are we from, really?
Mary Jo Arnoldi, curator of Africa Voices and chair of the museum’s
Department of Anthropology stated,  “that our human species evolved in
Africa and we all share the same ancestry at this most profound level.”
“Our human species evolved in Africa and we all share the same ancestry at this most profound level.” 
But African-Americans want to search for ancestors who crossed the oceans – willingly
 or unwillingly – in the last 500 years.
Testing companies are using that scientific innovation and research to enrich African Americans’ search for their cultural and genetic roots by identifying more specific
 geographic locations and ethnic groups. With larger and better-researched reference populations, geographical localization will improve. But even the best estimates are based
 on statistical probability. One respected company requires 70% confidence to report a
 given result – a reasonable standard, but that 30% leaves a lot of wiggle room!
Types of DNA testing: What can they tell you?
Wall of ACGT characters
Most testing companies analyze three types of DNA:  mitochondrial (mtDNA), Y chromosomes, and autosomal DNA. A woman’s egg passes mtDNA to her children, whether boys or girls, but a sperm’s few mitochondria don’t persist after fertilization. All of your mitochondria contain your mother’s mtDNA, and all her mitochondria contain hermother’s mtDNA, so only one of your eight great-grandparents (your mother’s mother’s mother) contributed your mtDNA. The other seven are not represented, and this ratio gets progressively tinier the further back you go. 

The Y chromosome passes from father to son and genetically defines a human male. Only males can transmit a Y chromosome, and only males inherit them. A man’s Y chromosome can be traced to his father’s, father’s, father’s, father – and farther. But, as with mtDNA, this represents
only one man in each generation – one out of 16 great-great-grandparents.
Autosomes are the 22 chromosome pairs that aren’t X or Y. Half come from your
mother,  half from your father – each parent contributes one of each pair.
But during egg or sperm formation, chromosomes are mixed and matched, dealing
out randomly assorted chromosomes from each grandparent – and here genetic
genealogy gets really fascinating! Scientists are starting to pinpoint small sections
of each chromosome, finding their probable origins in African, Asian, European,
Jewish, or Native American gene pools.  
What do our origins tell us about ourselves?
DNA evidence can also carry meanings that reach beyond historical records.
A husband-wife team of intermedia artists – Dr. Mendi and Keith Obadike – described
their “American Cypher Project,” which examines American stories about race and DNA.
Starting with the relationship of Thomas Jefferson and Sally Hemmings, they asked:
 How has DNA evidence changed the way people talk about that story? How does
it raise different questions? What do people think DNA does?
Family History Documents
Paper trails, old photos, and family stories
contain inconsistencies and gaps. But people
tend to expect precision and infallibility from
DNA science.

And yet: “We were really sort of inspired by how ambiguous some of the science was, or how inconclusive it was,” Keith said. “As artists we
 thrive on ambiguity. It’s like when all the
answers aren’t there, so we can really generate
some … We don’t know how you feel about
it as scientists,
but for us, it’s a goldmine.”
Speaker, Dr. Sandra Soo-Jin Lee
picked up these ambiguities in her survey
 research,  which asked the question: “An
individual who identifies as African-American receives genetic ancestry test results
 that indicate that she has 0% African ancestry, 87% European and 13% Asian ancestry.
I would classify her as _______.”  16% of respondents chose: “What she said is
what she is, African-American”; 2% picked Asian-American, 18% said
European-American, and 41% said “other”; the remaining 23% “don’t know.” 
The survey allowed respondents to explain their choice of “other.” Write-ins included:
 lab mix-up; mixed race, but it’s not up to me to decide; African-American is a
cultural identity,
not about a “racial blood quantum”; I’d call her Eurasian; and, I’d need to know
why the classification: social and cultural might be African-American, but to tailor drugs/treatments
for medical purposes, then European/Asian would be most important.
 “Has DNA testing made genealogy simpler or more complex?” It does depend who you ask. 
So we ask again, “Has DNA testing made genealogy simpler or more complex?” It does depend who you ask. But more and more people are asking, and the answers
extend far beyond the sequence of bases in DNA, encountering issues of culture,
 history, and personal identity.  
“Over the past several years, the National Museum of African American History and
Culture has produced a very ambitious series of engaging programs with a primary
focus on historical events or figures and the vibrancy of  African American culture
and art,” said Dierdre Cross, program coordinator at the NMAAHC. But “the
African Diaspora Symposium … added another dimension to our
programming: to have our audience participate in discussions focused on scientific
innovation, as represented by genomic research, and its direct impact
on African American health issues and community history.”
* held September 12, 2013, at the Smithsonian National Museum of
Natural History, Washington, DC
Resources
(1) Author, Scientist Assist in Tracing Lineage. National Public Radio.
(2) Ancestry-informative Markers Explained .Talking Glossary of Genetic Terms, National Human Genome Research Institute. 
(3)  The African Diaspora Symposium: Integrating Culture, Genomics, and History. National Human Genome Research Institute.




Friday, December 9, 2016

Before You Buy a DNA Test

Before You Buy

From ISOGG Wiki

This guide provides advice on some points to consider before you buy a DNA test.
  • Clarify your goals. What do you hope to learn from a DNA test? Which DNA test(s) should you or your relatives take to address your questions? Consult the beginners' guides to genetic genealogy for more insights. Don't hesitate to seek advice about your specific scenario on some of the genetic genealogy mailing lists. The DNA-NEWBIE list is a good place to start.
  • You may need to lower your expectations a bit. DNA is a "novel, objective, and independent form of evidence,"[1] yet uncertainties may remain. The nomenclature or the interpretation of your results may change over time. Each type of DNA test has its limitations. You may not have an immediate match in a Y chromosome or mtDNA database. Your haplogroup may not tell you exactly where your paternal or maternal line originated. Autosomal DNA tests may not identify a known fourth cousin or break down that brick wall. Admixture percentages may show inconsistencies from company to company and fail to detect small components of your ancestry. In spite of all those caveats, success stories do abound.
  • Ask yourself if you really want to know. A DNA test can sometimes provide surprising results, which might challenge your sense of ethnic identity, contradict your laborious genealogical research, or reveal unsuspected relationships. Your results may have an impact on your family members as well. You are your own best judge of your ability to handle the unexpected.
  • Do some comparison shopping. See the list of DNA testing companies, which also has links to side-by-side comparison charts for different types of tests.

Genetics of Disease with Patients in Africa

African researchers work through logistical, financial barriers to understand the genetics of disease

Doctor consulting with patients in Africa. Credit: Joseph Sohm, Shutterstock.com
Doctor with Patients in Africa














National Institute of Health-backed African scientists are engaged in a global research endeavor to understand the genetic basis of disease in all populations. But this can only be done by including populations that are the most genetically diverse.
Studies have shown that African populations contain the oldest and most diverse set of human genes. However, most studies of the human genome have focused on European ancestry populations. By not exploring genetic variation within African populations, opportunities are missed to advance not only the understanding of disease within those populations, but also for humans across the globe.
In 2010, the National Institutes of Health (NIH) Common Fund and the United Kingdom's Welcome Trust, in partnership with the African Society of Human Genetics, introduced the Human Heredity and Health in Africa(H3Africa) program. H3Africa supports African scientists conducting research on the genetic and environmental factors of disease. Five years after the program's first grants were awarded, researchers are building collaborative research networks, designing education and training initiatives, developing ethics guidelines for conducting research on African populations, and making discoveries about genetics and human health.
Yet, for H3Africa researchers, the path forward has not been without its challenges.
Language barriers, consent concerns 
Language, culture and the education level of study subjects can make research challenging for African researchers. Jantina De Vries, D.Phil., a researcher at the University of Cape Town in South Africa, coordinated a study on rheumatic heart disease, performing blood draws and heart imaging on thousands of healthy participants. Unfortunately, she said, the participants thought they were being screened for rheumatic heart disease, which they were told about in the consent process. 
"No matter how we tried to address this, it was difficult to correct this misunderstanding," said Dr. De Vries.
"Genomics research is very new on parts of the continent and it's often difficult to describe concepts like genes and genomics in local languages," said Paulina Tindana, Ph.D., an H3Africa-funded bioethicist at the Navrongo Health Research Centre in Ghana. "The dialect and the description of the research have to be appropriate for local people to give consent to participate."
Dr. Tindana and her colleagues work with H3Africa scientists to ensure they're using culturally relevant consent forms. Creativity and flexibility are important; some research groups translate consent forms into local languages, while other groups use agricultural references to help explain how people can inherit diseases and traits. One group produced a series of comic books with culturally appropriate superheroes to help local youth understand genomics.
Despite these challenges, there is no lack of enthusiasm for the research.  "Many genomics studies have implications for both individuals and communities, so it's helpful to engage communities where research is done and explain why it can be important," said Dr. Tindana. "They want to be partners in research."
Logistical, geographical barriers
Christian Happi,Ph.D., professor in the Department of Biological Sciences at Redeemer's University in Ede,Osun State, Nigeria, knows all too well that long delays in getting supplies and expensive equipment can also hinder research progress. "The supply chain represents a big problem...and we are dependent on other countries like the United States for reagents and equipment."
Dr. Happi's collaborators at Harvard University provide him with the needed materials, but using middlemen to purchase materials can cost three times as much as buying directly in the United States. Even so, his group studying fevers in rural areas of Sierra Leone and Nigeria was at the forefront of the Ebola crisis and was instrumental in containing the spread of the disease in Nigeria. 
In addition to the high cost of research materials, the continent's geography can represent a challenge to African researchers. Storing and transporting patient samples, particularly from rural villages to cities, isn't always successful and can take days on the road. Michele Ramsay, Ph.D., professor in the Division of Human Genetics at the National Health Laboratory Service and University of Witwatersrand in Johannesburg, South Africa, said that crossing borders with biological materials is often problematic: Fragile samples can get held up for weeks in customs. Scientists from her team hand-carry samples across difficult terrain and collaborators make sure dry ice is delivered daily to Customs during the clearance process.
"The resiliency and determination of the scientists and the people they are studying is incredibly inspiring," said Jennifer Troyer, Ph.D., H3Africa program director at the National Human Genome Research Institute (NHGRI), who helps coordinate the NIH-funding. "If something can't be done in one way, they find another way to do it. If there is one thing I have learned from working with this program, it's how to turn challenges into opportunities."
Looking ahead
H3Africa is currently funded for more than $76 million over five years, and consists of 25 projects in 27 African countries that include biomedical and ethical research projects, a bioinformatics network, and three biorepositories in Nigeria, Uganda and South Africa, respectively. The repositories will eventually house biological samples for over 75,000 research participants.
The NIH Common Fund, along with NHGRI and other NIH institutes, and their partner funding agencies the Wellcome Trust and the Alliance for Accelerating Excellence (AESA), have committed to five more years of investment in H3Africa, but after that, it will likely be up to the researchers to find other sources of funding. 
Dr. Troyer believes that greater investment by local governments in research, commerce, infrastructure and health care would help reduce some of the economic barriers to successful research.
H3Africa researchers hope to have a lasting effect both in improving the climate for collaborative genomics research in Africa and in implementing scientific discoveries for better health and hope the project can one day be self-sustained.
"If we can demonstrate our results can make a difference to patients and in training the next generation of African scientists," said Dr. Ramsay, "we can work through the public health systems to make a change."
Last Updated: December 6, 2016
National Institute of Health Genome Research Institute